The Institute of Experimental Medicine of the ASCR in cooperation with the Czech Neuroscience Society, The Slovak Society for Neuroscience and The Austrian Alzheimer Society organized the FENS Featured Regional Meeting. This Federation of European Neuroscience Societies event met September 9–11, 2013 at the Prague Congress Centre. More than 600 active participants from around the world participated in a broad program covering important areas of current neuroscience research. The scientific program consisted of four plenary lectures, 18 symposiums, six oral communication sessions and six special interest sessions by the world’s leading experts. In addition, acclaimed scientists and their students presented more than 350 posters during the course of the meeting.